Axsome Therapeutics (AXSM) Stock Overview
A biopharmaceutical company, develops and delivers novel therapies for the management of central nervous system (CNS) disorders in the United States. More details
| Snowflake Score | |
|---|---|
| Valuation | 2/6 |
| Future Growth | 6/6 |
| Past Performance | 0/6 |
| Financial Health | 4/6 |
| Dividends | 0/6 |
Rewards
Risk Analysis
No risks detected for AXSM from our risk checks.
AXSM Community Fair Values
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Analyst Price Targets
Axsome Therapeutics, Inc. Competitors
Price History & Performance
| Historical stock prices | |
|---|---|
| Current Share Price | US$235.97 |
| 52 Week High | US$236.84 |
| 52 Week Low | US$96.09 |
| Beta | 0.58 |
| 1 Month Change | 26.89% |
| 3 Month Change | 43.69% |
| 1 Year Change | 126.94% |
| 3 Year Change | 239.77% |
| 5 Year Change | 282.45% |
| Change since IPO | 2,599.89% |
Recent News & Updates
Seeking Alpha • May 14
Axsome's Auvelity: A New Treatment For Agitation In Alzheimer's Disease
Summary Axsome Therapeutics received FDA approval for Auvelity, the first non-psychotic agitation treatment in Alzheimer’s disease, addressing a significant unmet need. AXSM projects Auvelity sales of at least $8 billion, but this may be optimistic given the high annual cost, side effects, and the potential of alternative therapies. The stock has surged from around $3 in 2018 to over $200, driven largely by its Alzheimer’s program momentum and recent Auvelity approval. I anticipate a slight downward trend in AXSM's stock over the coming months, contingent on Auvelity sales and pipeline trial outcomes. Read the full article on Seeking AlphaAnalysis Article • May 07
Axsome Therapeutics, Inc. (NASDAQ:AXSM) Released Earnings Last Week And Analysts Lifted Their Price Target To US$270
Shareholders will be ecstatic, with their stake up 21% over the past week following Axsome Therapeutics, Inc. 's...
Narrative Update • May 06
AXSM: Alzheimer’s Agitation Approval Will Drive Future Upside Potential
Axsome Therapeutics' updated analyst price target has shifted higher, with the fair value estimate moving from $223.99 to $266.94 as analysts factor in revised assumptions for revenue growth, profitability, and future P/E, while also acknowledging a slightly higher discount rate. Analyst Commentary Recent Street research on Axsome Therapeutics has been active, with multiple firms revisiting their price targets, fine tuning assumptions around Auvelity, the broader pipeline, and key regulatory milestones such as the AXS-05 PDUFA date for Alzheimer's disease Agitation.Recent updates
Seeking Alpha • May 14
Axsome's Auvelity: A New Treatment For Agitation In Alzheimer's Disease
Summary Axsome Therapeutics received FDA approval for Auvelity, the first non-psychotic agitation treatment in Alzheimer’s disease, addressing a significant unmet need. AXSM projects Auvelity sales of at least $8 billion, but this may be optimistic given the high annual cost, side effects, and the potential of alternative therapies. The stock has surged from around $3 in 2018 to over $200, driven largely by its Alzheimer’s program momentum and recent Auvelity approval. I anticipate a slight downward trend in AXSM's stock over the coming months, contingent on Auvelity sales and pipeline trial outcomes. Read the full article on Seeking AlphaAnalysis Article • May 07
Axsome Therapeutics, Inc. (NASDAQ:AXSM) Released Earnings Last Week And Analysts Lifted Their Price Target To US$270
Shareholders will be ecstatic, with their stake up 21% over the past week following Axsome Therapeutics, Inc. 's...Narrative Update • May 06
AXSM: Alzheimer’s Agitation Approval Will Drive Future Upside Potential
Axsome Therapeutics' updated analyst price target has shifted higher, with the fair value estimate moving from $223.99 to $266.94 as analysts factor in revised assumptions for revenue growth, profitability, and future P/E, while also acknowledging a slightly higher discount rate. Analyst Commentary Recent Street research on Axsome Therapeutics has been active, with multiple firms revisiting their price targets, fine tuning assumptions around Auvelity, the broader pipeline, and key regulatory milestones such as the AXS-05 PDUFA date for Alzheimer's disease Agitation.Narrative Update • Apr 21
AXSM: Alzheimer’s Agitation Decision Will Drive Future Upside Potential
Axsome Therapeutics’ fair value estimate has ticked up by about $0.33 to $223.99 as analysts factor in higher price targets clustered in the $202 to $251 range, supported by views on Auvelity traction, the potential AXS-05 approval in Alzheimer's disease agitation, and operating leverage. Analyst Commentary Recent research updates on Axsome Therapeutics show a cluster of higher price targets, with several firms adjusting their views following Q4 results, Auvelity trends, and upcoming AXS-05 catalysts.Narrative Update • Apr 07
AXSM: Priority Review In Alzheimer’s Agitation Will Drive Future Upside
Analysts have raised their blended price targets on Axsome Therapeutics by a few dollars, reflecting updated models that incorporate stronger Auvelity traction, the potential AXS-05 Alzheimer's disease agitation opportunity estimated at about $1.6 billion, and revised assumptions about improved operating leverage. Analyst Commentary Recent research updates around Axsome Therapeutics cluster around the same core themes you are likely tracking as an investor, including Auvelity execution, the potential AXS-05 Alzheimer's disease agitation opportunity, and the company's operating leverage and cash generation profile.Narrative Update • Mar 23
AXSM: Priority Review In Alzheimer’s Agitation Will Drive Future Upside
Analysts have raised their blended price targets on Axsome Therapeutics to a range of $202 to $251, citing ongoing Auvelity traction, expectations around the AXS-05 Alzheimer's disease agitation filing, and operating leverage across the broader pipeline as key factors supporting their updated views. Analyst Commentary Street research on Axsome Therapeutics has recently centered on product execution for Auvelity, the potential of AXS-05 in Alzheimer’s disease agitation, and the company’s ability to scale operations efficiently.Narrative Update • Mar 08
AXSM: Priority Review In Alzheimer’s Agitation Will Drive Future Upside
Analysts have lifted their average price target on Axsome Therapeutics by about $6 to roughly $222, citing continued Auvelity traction, expectations around AXS-05 in Alzheimer's disease agitation, and operating leverage supported by an expanding neuroscience pipeline. Analyst Commentary Recent Street research on Axsome Therapeutics points to a generally constructive view, with a series of price target increases clustered around the low to mid US$200s and a mix of Outperform, Buy, Equal Weight, and Overweight ratings.Narrative Update • Feb 21
AXSM: Priority Reviews And Late-Stage CNS Pipeline Will Drive Future Upside
Analysts have inched their fair value estimate for Axsome Therapeutics higher by about $0.65 to roughly $216 per share, reflecting a series of recent price target increases across the Street that cite stronger modeled profitability and updated assumptions around key assets and pipeline progress. Analyst Commentary Recent research on Axsome Therapeutics has been skewed toward higher valuation work, with several firms lifting their price targets and reaffirming positive ratings.Narrative Update • Feb 06
AXSM: Priority Reviews And Late-Stage CNS Portfolio Will Drive Upside
Axsome Therapeutics' updated analyst price target edges higher by about US$5 per share, with analysts pointing to refreshed models that factor in slightly stronger revenue growth expectations, modestly higher assumed valuation multiples, and recent positive readthrough from Auvelity and Sunosi sales and regulatory progress. Analyst Commentary Recent Street research on Axsome Therapeutics centers on updated models following preliminary Q4 results, Auvelity and Sunosi performance, and regulatory milestones tied to priority review decisions.Narrative Update • Jan 23
AXSM: Late-Stage CNS Franchise And Alzheimer’s Agitation Decision Will Drive Upside
Analysts have lifted their blended price target on Axsome Therapeutics by about $14, reflecting updated models that factor in recent Q4 revenue outperformance for Auvelity and Sunosi, an increased assumed revenue growth rate to 51.70%, and a higher future P/E of 20.59x. Analyst Commentary Recent Street research on Axsome Therapeutics has been active, with several bullish analysts lifting price targets following Q3 and preliminary Q4 updates for Auvelity and Sunosi, while one bearish analyst trimmed expectations.Narrative Update • Jan 08
AXSM: Late-Stage CNS Franchise And AXS-05 Readout Will Drive Upside
Narrative Update: Axsome Therapeutics Analysts have lifted their average price target for Axsome Therapeutics by about $15 per share, citing recent model updates that reflect slightly higher revenue growth assumptions, a modestly richer future P/E multiple, and Street research pointing to steady commercial progress for Auvelity, Symbravo and Sunosi, along with potential upside from the AXS-05 program. Analyst Commentary Bullish analysts are generally constructive on Axsome Therapeutics, pointing to product execution, model updates and potential pipeline upside as reasons for lifting their valuation work.Narrative Update • Dec 24
AXSM: Late-Stage CNS Pipeline Will Drive Future Upside Potential
Axsome Therapeutics' analyst price target edges higher by approximately $5 to the mid-$190s as analysts point to stronger long term revenue growth, expanding profit margin expectations, and resilient demand for key commercial assets as justification for the upward revision. Analyst Commentary Recent Street research on Axsome Therapeutics reflects a predominantly constructive stance, with multiple price target increases into the mid to high $180s.Analysis Article • Nov 07
Axsome Therapeutics, Inc. (NASDAQ:AXSM) Third-Quarter Results Just Came Out: Here's What Analysts Are Forecasting For Next Year
Investors in Axsome Therapeutics, Inc. ( NASDAQ:AXSM ) had a good week, as its shares rose 3.3% to close at US$139...Narrative Update • Nov 07
AXSM: Commercial Execution And Late-Stage Pipeline Will Drive Strong Upside Potential
Axsome Therapeutics' fair value estimate has been raised by analysts from $176.84 to $181.58. This change reflects upward price target revisions, as analysts express optimism about the company's progress toward profitability and effective commercial execution following recent quarterly results.
New Narrative • Apr 28
R&D Pipeline And NDAs Will Unlock New Approvals
Ongoing R&D and product launch efforts, including key NDA submissions, may significantly enhance future revenues through new product approvals.Seeking Alpha • Feb 20
Axsome Q4 Earnings: Revenues Rising, Skepticism Lingering
Summary Axsome Therapeutics' stock has risen 47% since my August recommendation, driven by FDA approvals and revenue growth, but I maintain a "sell" rating. Despite Auvelity's revenue growth, significant SG&A and R&D expenses persist, and Symbravo's market potential in the crowded migraine space remains uncertain. Axsome's pipeline includes high-risk CNS indications with historically high attrition rates, and recent trial results have been mixed, questioning future success. Financially, Axsome has solid liquidity with a cash runway into mid-2027, but sustained cash burn and lack of clear revenue breakaway warrant cautious investment. Read the full article on Seeking AlphaSeeking Alpha • Feb 11
Axsome Settling Teva Patent Litigation Is Another Positive Catalyst -- Upgrade
Summary Axsome Therapeutics, Inc.'s stock has surged over 30% since my last “Hold” rating, driven by key catalysts like the litigation settlement with Teva Pharmaceuticals, announced today. Axsome's Auvelity and Sunosi are crucial, with Auvelity expected to generate over 75% of 2025 revenues; as such, today's news is a significant win. Despite high competition in MDD and other markets, Axsome's pipeline, including AXS-07 and AXS-12, shows potential for substantial revenue growth. I now rate AXSM stock a “Buy,” anticipating ~$2.5bn peak revenues long-term, and potentially a double-digit billion market cap, given upcoming data catalysts and multiple “shots on goal." Read the full article on Seeking AlphaSeeking Alpha • Dec 31
Axsome Therapeutics Remains A Buy Despite AXS-05's Mixed Results
Summary Axsome Therapeutics shows strong revenue growth from Auvelity and Sunosi, with promising late-stage pipeline drugs for migraine, fibromyalgia, and narcolepsy. Late-stage pipeline milestones include AXS-07 for migraine (PDUFA: January 31, 2025), AXS-12 for narcolepsy, and AXS-14 for fibromyalgia. Despite mixed Phase 3 results for AXS-05 in Alzheimer's agitation, the overall data is favorable, supporting a bullish outlook. AXSM stock's valuation appears high, but its revenue potential and cash runway suggest it could become cash flow positive by 2025. Regulatory risks and premium valuation are concerns, but Axsome's diverse portfolio and successful IPs mitigate investment risks, making it a “Buy”. Read the full article on Seeking AlphaSeeking Alpha • Nov 29
Axsome: Focus On AXS-12 Targeting Narcolepsy, Which Just Released Positive Data
Summary Axsome's AXS-12 met its primary endpoint in a Phase 3 study, significantly reducing cataplexy attacks in narcolepsy patients, positioning it for an NDA submission. The narcolepsy market is substantial, with current treatments having issues like tolerability and efficacy, which AXS-12 aims to address effectively. Financially, Axsome has a market cap of $4.83bn, strong revenue growth, but a net loss, indicating a cash runway of four to five quarters. Axsome is in a catalyst-heavy period with multiple NDA submissions and upcoming trial results, making it a strong buy before the January PDUFA. Read the full article on Seeking AlphaSeeking Alpha • Nov 12
Axsome Therapeutics Q3 Earnings: Stay For The Near Term Catalysts, Then Sell
Summary Axsome Therapeutics' Q3 2024 earnings report shows a revenue beat with $104.8m, up 81% YoY, but net loss increased to $(64.6m). Despite positive market response and promising pipeline candidates, Axsome's profitability remains distant, with significant cash burn and competition from pharma giants. AXS-07 is likely to gain FDA approval in January for migraine treatment, while AXS-05 shows potential for Alzheimer's agitation, but “blockbuster” revenue status is uncertain. Management says it sees multi-billion dollar revenue potential in Solriamfetol, a drug acquired for $53m from Jazz Pharma — I don't agree. Given the high volatility and upcoming data readouts, holding AXSM stock may be wise, but selling on any price spike is recommended. Read the full article on Seeking AlphaSeeking Alpha • Oct 15
Axsome: AXS-07 And Its Upcoming Second PDUFA
Summary AXS-07, targeting chronic migraine, has shown promising results in Phase 3 trials but faced a CRL from the FDA due to CMC issues. The FDA has set a new PDUFA date for AXS-07 on January 31, 2025, potentially leading to a significant stock boost upon approval. Axsome's financials show a market cap of $4.1bn and a cash runway of 4-5 quarters, but risks include potential dilution and FDA approval uncertainty. Despite concerns, AXSM remains a strong biotech investment, with plans to hold and buy on dips, anticipating AXS-07's market potential. Read the full article on Seeking AlphaSeeking Alpha • Aug 06
Axsome's Auvelity: High Hopes Meet Hefty Bills (Rating Downgrade)
Summary Axsome Therapeutics reported Q2 2024 revenues of $87.2 million, with Auvelity sales growing 135% year-over-year. The company’s SG&A and R&D expenses significantly increased, leading to wider net losses despite revenue growth. Auvelity faces stiff competition in the depression market, with uncertain positioning and high marketing expenses. Given Axsome’s financial risks and high operational costs, I recommend a "sell" rating on AXSM stock. Read the full article on Seeking AlphaSeeking Alpha • Jul 23
Axsome Therapeutics: Lots Of Moving Parts
Summary Today, we circle back to mid-cap biopharma Axsome Therapeutics, which has multiple potential catalysts on the horizon. The company has two approved products on the market and the potential to have six FDA approved drugs by the end of 2025. Analyst firms are largely positive on the shares, and explosive sales growth is projected over the next few years. An updated analysis around Axsome Therapeutics follows in the paragraphs below. Read the full article on Seeking AlphaSeeking Alpha • May 10
Why Axsome Therapeutics Is A Promising Stock Pick In CNS Treatments
Summary Axsome Therapeutics develops treatments for CNS conditions, with two commercial products: Auvelity for major depressive disorders and Sunosi for sleep disorders. The company has a diverse pipeline targeting illnesses such as Alzheimer's disease, smoking cessation, migraine, narcolepsy, and more. Axsome's portfolio addresses the medical needs of over 150 million people and has the potential to generate peak sales of up to $16.5 billion. Axsome maintains a strong cash position and manageable debt. Significant revenue growth is projected, supporting its intense research efforts. I rate AXSM a “buy” due to its high potential in a large market and promising financial outlook despite inherent biotech risks. Read the full article on Seeking AlphaSeeking Alpha • Feb 21
Axsome: Unpacking Auvelity's First-Year Market Dynamics And Economic Challenges
Summary Auvelity shows growth with $130.1 million annual sales, impressive in a crowded depression treatment market. Axsome's Q4 reveals surging revenues but widened losses due to high R&D and SG&A expenses. The cash position is strong, however, net loss suggests potential future financing needs despite the company's confidence. My investment stance: "Hold" on AXSM, citing revenue growth and market position balanced by operational and financial risks. Read the full article on Seeking AlphaShareholder Returns
| AXSM | US Pharmaceuticals | US Market | |
|---|---|---|---|
| 7D | 4.1% | 5.4% | 1.2% |
| 1Y | 126.9% | 44.3% | 28.7% |
Return vs Industry: AXSM exceeded the US Pharmaceuticals industry which returned 44.3% over the past year.
Return vs Market: AXSM exceeded the US Market which returned 28.7% over the past year.
Price Volatility
| AXSM volatility | |
|---|---|
| AXSM Average Weekly Movement | 6.1% |
| Pharmaceuticals Industry Average Movement | 9.9% |
| Market Average Movement | 7.2% |
| 10% most volatile stocks in US Market | 16.4% |
| 10% least volatile stocks in US Market | 3.1% |
Stable Share Price: AXSM has not had significant price volatility in the past 3 months compared to the US market.
Volatility Over Time: AXSM's weekly volatility (6%) has been stable over the past year.
About the Company
| Founded | Employees | CEO | Website |
|---|---|---|---|
| 2012 | 1,220 | Herriot Tabuteau | www.axsome.com |
Axsome Therapeutics, Inc., a biopharmaceutical company, develops and delivers novel therapies for the management of central nervous system (CNS) disorders in the United States. The company’s commercial product portfolio includes Auvelity (dextromethorphan-bupropion), a N-methyl-D-aspartate receptor antagonist, sigma-1 receptor agonist, aminoketone, and CYP2D6 inhibitor indicated for the treatment of major depressive disorder in adults; Sunosi (solriamfetol), a dopamine and norepinephrine reuptake inhibitor, trace amine-associated receptor 1 agonist, and 5-HT1A agonist indicated for the treatment of excessive daytime sleepiness in patients with narcolepsy or obstructive sleep apnea; and Symbravo (MoSEIC meloxicam rizatriptan), or AXS-07, a rapidly absorbed, multi-mechanistic, selective COX-2 inhibitor, and 5-HT1B/1D agonist indicated for the acute treatment of migraine with or without aura. It also develops AXS-05 (dextromethorphan-bupropion), an investigational N-methyl-D-aspartate receptor antagonist, which has completed Phase III clinical trial to treat Alzheimer's disease agitation, as well as that has completed phase II clinical trial for the treatment of smoking cessation; AXS-12 (reboxetine), a highly selective and potent norepinephrine reuptake inhibitor and cortical dopamine modulator, which has completed Phase II trial to treat narcolepsy; AXS-14 (esreboxetine), a selective and potent norepinephrine reuptake inhibitor that has completed Phase III trial for the treatment of fibromyalgia and other conditions; and Solriamfetol, a dopamine and norepinephrine reuptake inhibitor, which is in Phase III trial for treating attention deficit hyperactivity, major depressive, binge eating, and excessive sleepiness associated with shift work disorder.
Axsome Therapeutics, Inc. Fundamentals Summary
| AXSM fundamental statistics | |
|---|---|
| Market cap | US$12.14b |
| Earnings (TTM) | -US$188.30m |
| Revenue (TTM) | US$708.24m |
17.1x
P/S Ratio-64.5x
P/E RatioIs AXSM overvalued?
See Fair Value and valuation analysisEarnings & Revenue
| AXSM income statement (TTM) | |
|---|---|
| Revenue | US$708.24m |
| Cost of Revenue | US$52.41m |
| Gross Profit | US$655.82m |
| Other Expenses | US$844.13m |
| Earnings | -US$188.30m |
Last Reported Earnings
Mar 31, 2026
Next Earnings Date
n/a
| Earnings per share (EPS) | -3.66 |
| Gross Margin | 92.60% |
| Net Profit Margin | -26.59% |
| Debt/Equity Ratio | 344.1% |
How did AXSM perform over the long term?
See historical performance and comparisonCompany Analysis and Financial Data Status
| Data | Last Updated (UTC time) |
|---|---|
| Company Analysis | 2026/05/26 05:47 |
| End of Day Share Price | 2026/05/22 00:00 |
| Earnings | 2026/03/31 |
| Annual Earnings | 2025/12/31 |
Data Sources
The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.
| Package | Data | Timeframe | Example US Source * |
|---|---|---|---|
| Company Financials | 10 years |
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| Analyst Consensus Estimates | +3 years |
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| Market Prices | 30 years |
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| Ownership | 10 years |
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| Management | 10 years |
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| Key Developments | 10 years |
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* Example for US securities, for non-US equivalent regulatory forms and sources are used.
Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.
Analysis Model and Snowflake
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Industry and Sector Metrics
Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.
Analyst Sources
Axsome Therapeutics, Inc. is covered by 36 analysts. 21 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.
| Analyst | Institution |
|---|---|
| Joel Beatty | Baird |
| Brian Skorney | Baird |
| null null | Baird |