Maze Therapeutics, Inc.

NasdaqGM:MAZE Stock Report

Market Cap: US$1.3b

Maze Therapeutics Past Earnings Performance

Past criteria checks 0/6

Maze Therapeutics's earnings have been declining at an average annual rate of -8.1%, while the Pharmaceuticals industry saw earnings growing at 9.4% annually. Revenues have been declining at an average rate of 88.1% per year.

Key information

-8.08%

Earnings growth rate

118.33%

EPS growth rate

Pharmaceuticals Industry Growth5.95%
Revenue growth rate-88.06%
Return on equity-35.86%
Net Margin-612.71%
Last Earnings Update31 Mar 2026

Recent past performance updates

No updates

Recent updates

Seeking Alpha Mar 27

Maze Therapeutics: MZE829 Presses Forward Despite Stock Price Drop

Summary I am initiating coverage on Maze Therapeutics (MAZE) with a "Buy" rating following positive phase 2 HORIZON data for MZE829 in APOL1-mediated kidney disease. MZE829 achieved a 35.6% mean reduction in proteinuria, exceeding the ≥30% uACR threshold required for clinical relevance and potential regulatory advancement. Despite a 37% stock drop post-data, I view the market reaction as overblown given the program’s success and planned pivotal trial initiation. The company maintains a strong cash position, funding operations into 2028, and has pipeline optionality with MZE782 targeting PKU and CKD in upcoming POC studies. Read the full article on Seeking Alpha
Analysis Article Dec 15

We're Not Worried About Maze Therapeutics' (NASDAQ:MAZE) Cash Burn

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Seeking Alpha Mar 26

Maze Therapeutics: Interesting Science But IPO-Related And Other Risks Exist

Summary Maze Therapeutics, a kidney disease therapy developer, recently IPO-ed with a market cap of $487mn and significant early-stage investor backing. Lead asset MZE829 targets APOL1 Kidney Disease, showing promise in preclinical studies and currently in a phase 2 trial. Financials reveal a cash runway of 6.4 quarters from September, with significant R&D and G&A expenses, and a potential price drop post-lockup period. Due to the lack of proof of concept and potential pricing pressures, I recommend avoiding investment in Maze Therapeutics for now. Read the full article on Seeking Alpha

Revenue & Expenses Breakdown

How Maze Therapeutics makes and spends money. Based on latest reported earnings, on an LTM basis.


Earnings and Revenue History

NasdaqGM:MAZE Revenue, expenses and earnings (USD Millions)
DateRevenueEarningsG+A ExpensesR&D Expenses
31 Mar 2620-12339115
31 Dec 250-13134108
30 Sep 250-10131103
30 Jun 253-743198
31 Mar 25168-262889
31 Dec 2416832683
30 Sep 24168-182677
30 Jun 24165-182577
31 Mar 240-792577
31 Dec 230-1002574

Quality Earnings: MAZE is currently unprofitable.

Growing Profit Margin: MAZE is currently unprofitable.


Free Cash Flow vs Earnings Analysis


Past Earnings Growth Analysis

Earnings Trend: MAZE is unprofitable, and losses have increased over the past 5 years at a rate of 8.1% per year.

Accelerating Growth: Unable to compare MAZE's earnings growth over the past year to its 5-year average as it is currently unprofitable

Earnings vs Industry: MAZE is unprofitable, making it difficult to compare its past year earnings growth to the Pharmaceuticals industry (-4.8%).


Return on Equity

High ROE: MAZE has a negative Return on Equity (-35.86%), as it is currently unprofitable.


Return on Assets


Return on Capital Employed


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Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2026/06/08 07:04
End of Day Share Price 2026/06/08 00:00
Earnings2026/03/31
Annual Earnings2025/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

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Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Maze Therapeutics, Inc. is covered by 12 analysts. 11 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Julian HarrisonBTIG
Debjit ChattopadhyayGuggenheim Securities, LLC
Ananda GhoshH.C. Wainwright & Co.