Next-generation Sequencing Will Expand Clinical Capabilities Despite Risks

Key Takeaways

• Expansion in clinical genomics and next-generation sequencing adoption is driving strong, recurring revenue growth and future earnings visibility.
  
• Ongoing innovation, multiomics expansion, and operational efficiency are enhancing gross margins and creating new growth opportunities.
  
• Persistent research budget constraints, regulatory risks in China, rising competition, commoditization, and clinical dependency threaten Illumina's revenue growth, margins, and market position.

Catalysts

Provides sequencing- and array-based solutions for genetic and genomic analysis in the Americas, Europe, Greater China, the Asia Pacific, the Middle East, and Africa.

• Strong and resilient growth in clinical applications-especially oncology, genetic disease testing, and reproductive health-continues to expand as genomic technologies become the standard of care, supporting both recurring revenues from consumables and long-term earnings visibility.
  
• Increasing adoption of next-generation sequencing for preventive healthcare and early disease detection is driving broader utilization of Illumina's platforms, particularly as clinical markets now represent over 60% of sequencing consumables, positioning the business for sustained volume and revenue growth.
  
• Ongoing innovation-evidenced by successful launches like MiSeq i100 Plus and increasing uptake of NovaSeq X-lowers barriers for new customer segments, enhances platform performance, and supports higher gross margins as transitions accelerate, particularly in the clinical segment.
  
• Strategic expansion into multiomics, notably the planned acquisition of SomaLogic and integration of proteomics capabilities, creates incremental growth opportunities by increasing the breadth of Illumina's data and platform offerings, contributing to future revenue and operating margin expansion.
  
• Operational efficiencies, disciplined cost controls, and targeted share repurchases have already resulted in notable operating margin and EPS improvements, and further scaling-along with tax headwinds turning into tailwinds-sets the stage for continued net margin and earnings growth over the next several years.

Illumina Future Earnings and Revenue Growth

Assumptions

• Analysts are assuming Illumina's revenue will grow by 3.6% annually over the next 3 years.
• Analysts assume that profit margins will shrink from 29.3% today to 18.4% in 3 years time.
• Analysts expect earnings to reach $873.5 million (and earnings per share of $5.66) by about September 2028, down from $1.3 billion today. However, there is a considerable amount of disagreement amongst the analysts with the most bullish expecting $1.0 billion in earnings, and the most bearish expecting $715.5 million.
• In order for the above numbers to justify the analysts price target, the company would need to trade at a PE ratio of 22.2x on those 2028 earnings, up from 12.0x today. This future PE is lower than the current PE for the US Life Sciences industry at 29.3x.
• Analysts expect the number of shares outstanding to decline by 3.09% per year for the next 3 years.
• To value all of this in today's terms, we will use a discount rate of 7.53%, as per the Simply Wall St company report.

Illumina Future Earnings Per Share Growth

Risks

• Heightened U.S. research funding uncertainty and ongoing NIH budget constraints are leading to persistent softness in the research end-market, significantly limiting instrument purchases and creating a negative long-term headwind for revenue growth and earnings diversification.
  
• Increased export restrictions and regulatory uncertainties in China are causing a sustained decline in Chinese instrument and consumables revenue; management notes the situation is currently unsustainable, indicating elevated risk to international revenue streams and future top-line growth.
  
• Intensifying competition, particularly from upcoming platforms like Roche's with faster turnaround times, poses the risk of price pressure, potential market share loss, and margin compression, especially as the market for high
• and mid-throughput sequencing matures.
  
• There is ongoing commoditization of next-generation sequencing (NGS) technology as well as a shift towards decentralized, benchtop sequencers like the MiSeq i100, which could lower barriers for competitors, shift purchasing patterns, and erode gross margins and operating leverage over time.
  
• The company's dependence on continued strong growth in clinical applications carries risk; if clinical adoption or reimbursement slows, demand for sequencing platforms and consumables could weaken, leading to lower revenue growth and potential negative impact on earnings and margins, especially as clinical now makes up over 60% of consumables revenue.

Valuation

• The analysts have a consensus price target of $111.952 for Illumina based on their expectations of its future earnings growth, profit margins and other risk factors. However, there is a degree of disagreement amongst analysts, with the most bullish reporting a price target of $185.0, and the most bearish reporting a price target of just $75.0.
• In order for you to agree with the analyst's consensus, you'd need to believe that by 2028, revenues will be $4.8 billion, earnings will come to $873.5 million, and it would be trading on a PE ratio of 22.2x, assuming you use a discount rate of 7.5%.
• Given the current share price of $98.22, the analyst price target of $111.95 is 12.3% higher. Despite analysts expecting the underlying buisness to decline, they seem to believe it's more valuable than what the market thinks.
• We always encourage you to reach your own conclusions though. So sense check these analyst numbers against your own assumptions and expectations based on your understanding of the business and what you believe is probable.