Iovance Biotherapeutics (IOVA) Stock Overview
A commercial-stage biopharmaceutical company, develops and commercializes cell therapies using autologous tumor infiltrating lymphocyte for the treatment of metastatic melanoma and other solid tumor cancers in the United States and internationally. More details
| Snowflake Score | |
|---|---|
| Valuation | 3/6 |
| Future Growth | 5/6 |
| Past Performance | 0/6 |
| Financial Health | 5/6 |
| Dividends | 0/6 |
IOVA Community Fair Values
Create NarrativeSee what 175 others think this stock is worth. Follow their fair value or set your own to get alerts.
Analyst Price Targets
Top Community Narratives
Iovance Biotherapeutics
44.3% undervalued intrinsic discount
Why I think Iovance is undervalued
View narrativePO
Published 3 Jul
Iovance Biotherapeutics, Inc. Competitors
Price History & Performance
| Historical stock prices | |
|---|---|
| Current Share Price | US$10.02 |
| 52 Week High | US$10.98 |
| 52 Week Low | US$1.76 |
| Beta | 0.83 |
| 1 Month Change | 42.53% |
| 3 Month Change | 156.27% |
| 1 Year Change | 355.45% |
| 3 Year Change | 99.01% |
| 5 Year Change | -60.86% |
| Change since IPO | 92.39% |
Recent News & Updates
Narrative Update • Sep 03
IOVA: Post Q2 Share Surge Will Test Sustainability Of Upcoming Sales Targets
Analysts have raised the fair value narrative for Iovance Biotherapeutics from $4.00 to $6.00, as a series of higher price targets across the Street cites stronger Amtagvi revenue trends, improving margins, and updated company models following recent Q2 results. Analyst Commentary Recent Street research on Iovance Biotherapeutics clusters around a similar message.Seeking Alpha • Aug 20
Iovance Biotherapeutics: Breakout Quarter, Catalysts Ahead, And Competitor Updates
Summary Iovance Biotherapeutics, Inc. delivered a breakout Q2 '26 for Amtagvi sales, with management guiding for further growth ahead. IOVA's maturing clinical pipeline and imminent NSCLC readout position the company for further upside, given the market potential in NSCLC is several times larger than in melanoma. Potential competitor, IMTX, is expecting to produce results from a trial of its cell therapy, Anzu-cel, in melanoma in H1 '27. IOVA risks include disappointing clinical data, clinical delays, or subpar sales performance, among other risks. Read the full article on Seeking Alpha
Narrative Update • Aug 20
IOVA: TIL Therapy Progress And Margin Expansion Will Drive Future Repricing
Analysts lifted the fair value estimate for Iovance Biotherapeutics from $8.22 to $9.33, citing higher modeled revenue growth, improved profit margin assumptions, and a lower forward P/E following recent price target increases tied to Amtagvi outperformance and stronger gross margins. Analyst Commentary Recent research on Iovance Biotherapeutics focuses heavily on Amtagvi revenue trends, margin performance, and how much of that progress may already be reflected in the current share price.Recent updates
Narrative Update • Sep 03
IOVA: Post Q2 Share Surge Will Test Sustainability Of Upcoming Sales Targets
Analysts have raised the fair value narrative for Iovance Biotherapeutics from $4.00 to $6.00, as a series of higher price targets across the Street cites stronger Amtagvi revenue trends, improving margins, and updated company models following recent Q2 results. Analyst Commentary Recent Street research on Iovance Biotherapeutics clusters around a similar message.Seeking Alpha • Aug 20
Iovance Biotherapeutics: Breakout Quarter, Catalysts Ahead, And Competitor Updates
Summary Iovance Biotherapeutics, Inc. delivered a breakout Q2 '26 for Amtagvi sales, with management guiding for further growth ahead. IOVA's maturing clinical pipeline and imminent NSCLC readout position the company for further upside, given the market potential in NSCLC is several times larger than in melanoma. Potential competitor, IMTX, is expecting to produce results from a trial of its cell therapy, Anzu-cel, in melanoma in H1 '27. IOVA risks include disappointing clinical data, clinical delays, or subpar sales performance, among other risks. Read the full article on Seeking AlphaNarrative Update • Aug 20
IOVA: TIL Therapy Progress And Margin Expansion Will Drive Future Repricing
Analysts lifted the fair value estimate for Iovance Biotherapeutics from $8.22 to $9.33, citing higher modeled revenue growth, improved profit margin assumptions, and a lower forward P/E following recent price target increases tied to Amtagvi outperformance and stronger gross margins. Analyst Commentary Recent research on Iovance Biotherapeutics focuses heavily on Amtagvi revenue trends, margin performance, and how much of that progress may already be reflected in the current share price.Narrative Update • Aug 06
IOVA: TIL Therapy Pipeline Progress Will Drive Future Repricing
Analysts have trimmed their price target for Iovance Biotherapeutics to $8.22 from $8.80, reflecting updated assumptions on fair value, discount rate, revenue growth, profit margin, and a future P/E now at 153.15x. What’s in the News for Iovance Biotherapeutics Iovance Biotherapeutics received conditional approval from the Therapeutic Goods Administration of Australia for Amtagvi (lifileucel) to treat previously treated advanced melanoma.Narrative Update • Jul 23
IOVA: Lung Cancer Trials And 2026 Guidance Will Drive Future Repricing
Analysts have modestly adjusted their outlook on Iovance Biotherapeutics, with the updated fair value estimate moving to $8.80 from $8.35 as they factor in revised assumptions on the discount rate, revenue growth, profit margin, and future P/E expectations. What’s in the News for Iovance Biotherapeutics Iovance Biotherapeutics reaffirmed its full year 2026 revenue guidance of US$350 million to US$370 million and Q2 2026 guidance of US$86 million to US$88 million, according to its updated corporate presentation.
New Narrative • Jul 03
Why I think Iovance is undervalued
In my opinion, Iovance is one of those biotech companies where the market is still focused on what went wrong in the past instead of what could happen over the next few years. After a disappointing commercial launch in 2025, many investors lost confidence and the share price fell sharply.
Narrative Update • Jun 17
IOVA: Replimune Setback And IL 12 TIL Trial Will Support Higher P/E
The analyst price target for Iovance Biotherapeutics has been trimmed by $2 as analysts factor in updated competitive expectations following recent developments at Replimune while still reflecting broadly consistent fair value and growth assumptions. Analyst Commentary Recent research on Iovance Biotherapeutics centers on how competitive developments and regulatory news in skin cancer treatments may influence sentiment on the stock.Narrative Update • Jun 03
IOVA: Competitive Setbacks And New IL 12 Program Will Support Higher Future P/E
Analysts have modestly adjusted their outlook on Iovance Biotherapeutics, with recent price target changes including UBS moving to $4 from $2 and Chardan trimming its target by $2. These revisions reflect mixed views on fundamentals, the pace of Amtagvi uptake, and potential benefits from a competing product setback.Narrative Update • May 14
IOVA: Margin Gains And 2026 Sarcoma Readouts Will Support Higher Future P/E
Analysts have trimmed the fair value estimate for Iovance Biotherapeutics to $14.00 from $16.00, reflecting updated views on revenue growth potential, margin trajectory, and a higher future P/E multiple, following recent research highlighting both Q4 operational progress and ongoing uncertainties around Amtagvi acceleration. Analyst Commentary Recent Street research shows a mixed but generally constructive tone around Iovance Biotherapeutics, with several bullish analysts highlighting improving execution in Q4, progress on margins, and potential benefits from external events in the competitive set.Analysis Article • May 11
Iovance Biotherapeutics, Inc. (NASDAQ:IOVA) First-Quarter Results: Here's What Analysts Are Forecasting For This Year
Iovance Biotherapeutics, Inc. ( NASDAQ:IOVA ) missed earnings with its latest first-quarter results, disappointing...Narrative Update • Apr 29
IOVA: Q4 Margin Progress And Sarcoma Data Will Drive Upside Potential
Narrative Update: Iovance Biotherapeutics The analyst price target for Iovance Biotherapeutics has been lifted to $4. This reflects updated models that incorporate Q4 fundamentals, margin progress and expectations around Amtagvi and broader trial momentum, while still acknowledging areas of uncertainty highlighted by recent Street research.Narrative Update • Apr 14
IOVA: Q4 Margin Gains And Sarcoma Data Are Expected To Drive Upside
The average analyst price target for Iovance Biotherapeutics has moved higher toward $4, supported by research citing improved Q4 fundamentals, margin progress, and early signs that initial launch issues may be easing. Analyst Commentary Recent research highlights a mix of optimism around product execution and margins alongside pockets of caution on valuation and growth risks.Narrative Update • Mar 31
IOVA: Margin Progress And 2026 Sarcoma Data Outlook Will Support Higher Future P/E
The analyst fair value estimate for Iovance Biotherapeutics has been adjusted from $17.00 to $16.00, reflecting updated views on revenue growth, margins, and future P/E assumptions as analysts respond to recent price target moves and Q4 results across the Street. Analyst Commentary Street research around the latest quarter points to a generally constructive shift in sentiment, with several bullish analysts lifting price targets and, in one case, upgrading the rating on Iovance Biotherapeutics.Narrative Update • Mar 16
IOVA: Fair Outlook Balances Q4 Progress With 2026 Clinical And Launch Risks
The analyst price target for Iovance Biotherapeutics has shifted from $2 to $4 as analysts point to stronger Q4 fundamentals, improving margins, ongoing manufacturing progress, and early signs that some initial launch issues for Amtagvi may be easing, even while longer term revenue acceleration remains uncertain. Analyst Commentary Recent Street research around Iovance Biotherapeutics reflects a mixed setup, with price target changes clustered across a wide range and ratings spanning Neutral to Buy.Narrative Update • Mar 02
IOVA: Elevated Future P/E Will Likely Clash With 2026 Clinical Data Risks
Analysts have lifted their price targets on Iovance Biotherapeutics from a range starting at $3 to as high as $16, citing Q4 revenue momentum, improving gross margins and manufacturing efficiency, and expectations for more clinical data in 2026. Analyst Commentary Recent research highlights a split in how Wall Street views Iovance Biotherapeutics, with some firms lifting price targets on the back of Q4 execution and others trimming expectations while still acknowledging operational progress.Narrative Update • Feb 16
IOVA: Elevated Future P/E Will Likely Expose Execution Risk
Analysts have raised their price target on Iovance Biotherapeutics by $0.50, citing updated assumptions around fair value, growth, margins, and future P/E that reflect recent Street research. Analyst Commentary Recent Street research on Iovance Biotherapeutics has highlighted a mix of optimism and caution around the updated price target, with some readers likely to focus less on the small US$0.50 change and more on what it implies about risk and execution.Narrative Update • Feb 02
IOVA: Reaffirmed 2025 Revenue Outlook Will Support A Higher Future P/E
Analysts have trimmed their fair value estimate for Iovance Biotherapeutics from US$20.00 to US$17.00, citing updated assumptions that include a slightly higher discount rate, a lower projected revenue growth rate, a modestly higher profit margin, and a reduced future P/E multiple. What's in the News Iovance Biotherapeutics reaffirmed its full year 2025 revenue guidance, keeping the expected range at US$250 million to US$300 million for the first full calendar year of Amtagvi sales (Key Developments).Narrative Update • Jan 19
IOVA: Lung Cancer Trial Progress Will Drive Bullish Repricing Ahead
Analysts have kept their price target for Iovance Biotherapeutics steady at US$8.35, citing only minor tweaks to inputs such as the discount rate and long term P/E assumptions rather than any fundamental shift in their outlook. What's in the News Iovance Biotherapeutics reaffirmed its full year 2025 revenue guidance, keeping the range at US$250 million to US$300 million for the first full calendar year of Amtagvi sales (Company guidance).Narrative Update • Jan 05
IOVA: Future Lung Cancer Data Will Drive Renewed Bullish Momentum
Analysts have modestly increased their price target on Iovance Biotherapeutics by 0.10 dollars to reflect slightly lower perceived risk, as seen in a reduced discount rate, while maintaining robust long term revenue growth and profit margin expectations alongside a marginally higher future price to earnings multiple. What's in the News Iovance reaffirmed its full year 2025 revenue guidance of 250 to 300 million dollars for the first full calendar year of Amtagvi sales, signaling confidence in launch momentum (company guidance) Interim data from the registrational Phase 2 IOV-LUN-202 trial showed a 25.6 percent objective response rate for lifileucel monotherapy in previously treated advanced nonsquamous NSCLC without actionable mutations, including 2 complete and 7 partial responses and a 71.8 percent disease control rate (company trial update) The median duration of response for lifileucel in IOV-LUN-202 has not yet been reached after a median follow up of 25.4 months, indicating durable benefit among responding NSCLC patients (company trial update) Valuation Changes Fair Value: increased slightly from 8.25 dollars to 8.35 dollars, reflecting a modest uplift in the intrinsic valuation estimate.Narrative Update • Dec 15
IOVA: Future Lung Cancer Data Will Drive Renewed Bullish Momentum
Analysts have modestly reduced their price target on Iovance Biotherapeutics to reflect slightly slower projected revenue growth, a meaningfully lower long term profit margin outlook, and a higher assumed future price to earnings multiple, while leaving the estimated fair value effectively unchanged at about 8.25 dollars per share. What's in the News Iovance Biotherapeutics reaffirmed its full year 2025 revenue guidance, targeting between 250 million dollars and 300 million dollars in the first full calendar year of Amtagvi sales (company guidance).Narrative Update • Nov 30
IOVA: Future Phase 2 Data Will Drive Renewed Bullish Momentum
Analysts have raised their price target for Iovance Biotherapeutics from $7.75 to $8.25 per share, citing updated financial metrics and modestly adjusted long-term growth assumptions. What's in the News Iovance Biotherapeutics reaffirmed its revenue guidance for the full year 2025, projecting $250 to $300 million in the first full calendar year of Amtagvi sales.Narrative Update • Nov 16
IOVA: Future Profitability Outlook Will Drive Renewed Investor Interest
Analysts have adjusted their price target for Iovance Biotherapeutics from $8.00 to $7.75. This change reflects updated views on the company's growth trajectory and profitability outlook.Analysis Article • Nov 08
Here's What Analysts Are Forecasting For Iovance Biotherapeutics, Inc. (NASDAQ:IOVA) After Its Third-Quarter Results
Shareholders of Iovance Biotherapeutics, Inc. ( NASDAQ:IOVA ) will be pleased this week, given that the stock price is...Narrative Update • Nov 02
IOVA: Advanced Melanoma Approval and Equity Raise Will Drive Upside Potential
Analysts have lowered their price target for Iovance Biotherapeutics from $9.10 to $8.00. They cite updated expectations for slower revenue growth, compressed profit margins, and a higher required rate of return.Narrative Update • Aug 25
Oncology Expansion And Global Approvals Will Unlock Future Markets
The consensus analyst price target for Iovance Biotherapeutics has been revised downward to $9.10 as slower-than-expected Amtagvi commercial adoption and logistical challenges outweigh positive early clinical response data. Analyst Commentary Bearish analysts cite a slower-than-expected commercial launch for Amtagvi in second-line melanoma, driving down sentiment and price targets.Narrative Update • Aug 10
Oncology Expansion And Global Approvals Will Unlock Future Markets
The decrease in Iovance Biotherapeutics' consensus price target is primarily driven by a reduction in expected annual revenue growth from 49.7% to 45.5%, resulting in a lowered fair value estimate from $10.00 to $9.10. What's in the News Five-year results from the Phase 2 C-144-01 trial showed Amtagvi (lifileucel) produced a median OS of 13.9 months and a 31.4% objective response rate in advanced melanoma patients; 19.7% survived at five years with durable responses and no new safety concerns.Analysis Article • Jul 22
Iovance Biotherapeutics, Inc. (NASDAQ:IOVA) Shares Fly 26% But Investors Aren't Buying For Growth
Iovance Biotherapeutics, Inc. ( NASDAQ:IOVA ) shareholders are no doubt pleased to see that the share price has bounced...Analysis Article • May 16
Iovance Biotherapeutics, Inc.'s (NASDAQ:IOVA) 46% Dip In Price Shows Sentiment Is Matching Revenues
Unfortunately for some shareholders, the Iovance Biotherapeutics, Inc. ( NASDAQ:IOVA ) share price has dived 46% in the...Analysis Article • May 13
News Flash: 12 Analysts Think Iovance Biotherapeutics, Inc. (NASDAQ:IOVA) Earnings Are Under Threat
The analysts covering Iovance Biotherapeutics, Inc. ( NASDAQ:IOVA ) delivered a dose of negativity to shareholders...
New Narrative • Apr 22
US Launch And Global Expansion Will Create New Opportunities
The U.S. launch of Amtagvi and international expansion could drive significant revenue and market growth, enhancing revenue streams and market share.Seeking Alpha • Apr 22
Iovance Biotherapeutics: Only For The Brave
Summary Shares of Iovance Biotherapeutics have plummeted post-Amtagvi approval due to excessive ATM usage and 7% shareholder dilution, despite solid financials and reaffirmed FY25 outlook. Iovance's TIL therapy, Amtagvi, is FDA-approved for advanced melanoma and is in trials for other oncology indications, including NSCLC and endometrial cancer. Despite significant cash burn and unprofitability until at least FY27, Iovance's extensive trials and potential blockbuster status for Amtagvi present multi-bagger potential. An analysis around Iovance Biotherapeutics follows in the paragraphs below. Read the full article on Seeking AlphaSeeking Alpha • Mar 18
Iovance: The Company Makes It Hard To Estimate Revenue Growth
Summary Iovance reported Q4'24 revenues of $25M from Proleukin, a 51% increase from the prior quarter, but Amtagvi revenues of 48.7M, were up just 16% from the prior quarter. Proleukin revenues could be a leading indicator for Amtagvi revenues, but the company also supplied a new distributor in Q4'24, making it hard to judge Q1'25 Amtagvi growth. Obsidian Therapeutics represents a relevant competitor with a cell therapy called OBX-115, that has potential advantages over lifileucel, although IOVA has its own next-gen therapies in development. Read the full article on Seeking AlphaAnalysis Article • Mar 02
Iovance Biotherapeutics, Inc. (NASDAQ:IOVA) Just Reported Earnings, And Analysts Cut Their Target Price
There's been a major selloff in Iovance Biotherapeutics, Inc. ( NASDAQ:IOVA ) shares in the week since it released its...Seeking Alpha • Feb 28
Iovance's Q4: Execution Risks Mount As Infusion Growth Slows (Rating Downgrade)
Summary Iovance Biotherapeutics, Inc.'s valuation has halved since August; Amtagvi, its FDA-approved TIL therapy, generated $12.8M in initial revenue, but faces significant risks. Q3 and Q4 performances showed mixed results, with $42.1M and $48.7M in Amtagvi revenues, respectively, and a notable cash burn. Despite high costs and competition, Amtagvi remains a preferred option in PD-1-refractory melanoma, with plans to increase its price for better margins. Given the complex and costly nature of TIL therapy, I downgrade IOVA stock to “hold,” acknowledging both its potential and significant risks. Read the full article on Seeking AlphaAnalysis Article • Jan 11
Iovance Biotherapeutics, Inc. (NASDAQ:IOVA) May Have Run Too Fast Too Soon With Recent 25% Price Plummet
To the annoyance of some shareholders, Iovance Biotherapeutics, Inc. ( NASDAQ:IOVA ) shares are down a considerable 25...Seeking Alpha • Dec 17
Iovance Biotherapeutics: Amtagvi Launch Growing, But Stock Isn't
Summary Iovance's guidance for FY2025 is for total product revenues of $450M-$475M, reflecting confidence in Amtagvi's strong market launch. Preliminary Q4'24 numbers on patient infusions could be considered to reflect a slowing rate of growth, albeit still growth, or just some seasonality, among other possibilities. IOVA can nonetheless meet its FY2025 guidance, although timely approval ex-US of Amtagvi will likely be required, with UK approval in H1'25 and EU approval in H2'25 possible. Read the full article on Seeking AlphaSeeking Alpha • Nov 11
Iovance Biotherapeutics Q3: A Beat, But A Selloff - Now A Buy Opportunity
Summary Iovance Biotherapeutics' Q3 earnings outperformed expectations, with $58.6m in revenue, but shares fell due to high market expectations and competition concerns. Amtagvi, Iovance's lead drug, shows strong commercial potential with 2025 revenue guidance of $450-$475m and significant opportunities in melanoma and other cancers including NSCLC. Despite high cash burn and competition, Iovance's growth in revenue, reimbursement, and treatment centers suggests a “buy the dip” opportunity for risk-tolerant investors. The company is progressing towards profitability, with promising pipeline developments and potential 25-40% IOVA stock price growth over the next 12 months. Read the full article on Seeking AlphaSeeking Alpha • Oct 03
Iovance Biotherapeutics: Moving To The Next Phase
Summary Iovance Biotherapeutics' Amtagvi has gained rapid market traction post-FDA approval, with strong Q3 performance and promising revenue projections for 2024 and beyond. The company's growth prospects are bolstered by potential regulatory approvals in international markets and ongoing trials in other cancer types, including NSCLC. Despite the positive outlook, risks include market penetration challenges, regulatory hurdles, competition, and financial sustainability concerns due to ongoing cash burn. I am looking to add to my IOVA position at current valuations, anticipating a potential reversal and long-term growth. Read the full article on Seeking AlphaSeeking Alpha • Sep 06
Iovance Therapeutics: Historic Product, Tough Commercial Outlook
Summary Iovance's cell therapy Amtagvi has received an historic FDA approval for treating unresectable or metastatic melanoma, but its stock has fallen over 70% since 2020. Despite first revenues from Amtagvi and Proleukin in Q2, financial uncertainties and a high cash burn raise concerns about Iovance's long-term profitability and market viability. Management's lack of detailed revenue breakdown and challenges with insurance approvals and competition create a little uncertainty around Amtagvi's commercial success. While promising label expansions and full approval could boost prospects, current financial, regulatory, and commercial uncertainties justify maintaining a "Hold" rating. Read the full article on Seeking AlphaAnalysis Article • Aug 11
Earnings Update: Iovance Biotherapeutics, Inc. (NASDAQ:IOVA) Just Reported And Analysts Are Boosting Their Estimates
Iovance Biotherapeutics, Inc. ( NASDAQ:IOVA ) just released its quarterly report and things are looking bullish...Seeking Alpha • Aug 11
Iovance's Tumor-Fighting TILs Are Just Warming Up (Rating Upgrade)
Summary Iovance's Q2 2024 revenue of $31.1 million surpassed analyst expectations. Amtagvi, Iovance's TIL therapy, generated $12.8 million in its first full quarter post-approval. Iovance's ongoing trials in NSCLC and endometrial cancer could expand lifileucel's market potential. The company projects $160–$165 million in full-year 2024 revenue, with substantial growth expected by 2025. I am upgrading Iovance stock to a "buy" based on the improved outlook for Amtagvi and potential revenue growth. Read the full article on Seeking AlphaSeeking Alpha • Jun 26
Iovance Biotherapeutics: Amtagvi Launch Continues Upward
Summary The Amtagvi launch has seen over 100 patients enrolled for therapy since approval, with potential for Q2'24 earnings to reflect some initial sales. IOVA's enrollment of the TILVANCE-301 continues, with updates on enrollment serving as a potential catalyst. Key cohorts of a study of lifileucel in non-small cell lung cancer are set to complete enrollment in 2025. Read the full article on Seeking AlphaSeeking Alpha • May 10
Iovance Q1 Earnings Review: Not Enough Data To Draw Conclusions On Amtagvi
Summary Iovance Biotherapeutics reported its Q1 2024 earnings yesterday. The company made a net loss of $(113m), or $(0.42) per share. Iovance secured a historic approval for a first solid tumor targeting cell therapy in mid-Feb, triggering overnight gains of close to 100%. Now, the market is turning its attention to revenue figures and patient enrollment for Amtagvi, approved to treat melanoma. Yesterday's updates provided by management seemed upbeat, but analysts had many questions and the share price has been falling today. In this post, I provide a thorough overview of the state of play post Q1 '24 earnings, and speculate on key themes that will dictate IOVA stock price movements going forward. Read the full article on Seeking AlphaSeeking Alpha • Apr 09
Iovance Biotherapeutics: Riding The Favorable Moment Could Bring Excellent Results
Summary Iovance Biotherapeutics is experiencing a favorable moment following FDA approval for its melanoma drug Amtagvi and a successful underwritten offering. The company has developed its own production capacity and aims to become a global leader in TIL therapies for cancer patients. Insider ownership has increased by over 50%, indicating strong confidence in the company's future results. Read the full article on Seeking AlphaSeeking Alpha • Mar 25
Iovance Biotherapeutics: Initial Amtagvi Launch In Focus
Summary Iovance's tumor-infiltrating lymphocyte (TIL) product, Amtagvi, was recently approved by the FDA for the treatment of advanced melanoma patients who have failed a PD-1 blocking antibody. Initial numbers from the early days of the launch can be considered when trying to project revenues from Amtagvi going forward. IOVA can improve potential revenues by gaining approval of its TIL therapies like Amtagvi outside of the US and in new indications. In the short term, however, the focus may be on the current Amtagvi launch, where some success may already be reflected in the price. Read the full article on Seeking AlphaShareholder Returns
| IOVA | US Biotechs | US Market | |
|---|---|---|---|
| 7D | 23.1% | 1.2% | 0.5% |
| 1Y | 355.5% | 37.1% | 12.0% |
Return vs Industry: IOVA exceeded the US Biotechs industry which returned 37.1% over the past year.
Return vs Market: IOVA exceeded the US Market which returned 12% over the past year.
Price Volatility
| IOVA volatility | |
|---|---|
| IOVA Average Weekly Movement | 16.9% |
| Biotechs Industry Average Movement | 9.5% |
| Market Average Movement | 6.8% |
| 10% most volatile stocks in US Market | 15.2% |
| 10% least volatile stocks in US Market | 2.9% |
Stable Share Price: IOVA's share price has been volatile over the past 3 months compared to the US market.
Volatility Over Time: IOVA's weekly volatility (17%) has been stable over the past year, but is still higher than 75% of US stocks.
About the Company
| Founded | Employees | CEO | Website |
|---|---|---|---|
| 2007 | 975 | Frederick Vogt | www.iovance.com |
Iovance Biotherapeutics, Inc., a commercial-stage biopharmaceutical company, develops and commercializes cell therapies using autologous tumor infiltrating lymphocyte for the treatment of metastatic melanoma and other solid tumor cancers in the United States and internationally. The company offers Amtagvi, an individualized T cell therapy for solid tumor cancer and for the treatment of adult patients with previously treated advanced, or unresectable or metastatic melanomal; and Proleukin, an interleukin-2 product for the treatment of patients with metastatic melanoma and metastatic renal cell carcinoma. It also develops lifileucel for the treatment of melanoma, cervical cancer, non-small cell lung cancer (NSCLC), endometrial cancer, and head and neck squamous cell carcinoma (HNSCC); LN-145-S1 to treat melanoma and HNSCC; LN-145 Gen 3 and core biopsy for the treatment of NSCLC; LN-145 Gen 3 to treat melanoma and HNSCC; IOV-2001 to treat chronic lymphocytic leukemia and small lymphocytic lymphoma; IOV-4001 for the treatment of melanoma and NSCLC; and IOV-3001 for use in the TIL therapy treatment regimen.
Iovance Biotherapeutics, Inc. Fundamentals Summary
| IOVA fundamental statistics | |
|---|---|
| Market cap | US$4.47b |
| Earnings (TTM) | -US$289.52m |
| Revenue (TTM) | US$324.97m |
14.0x
P/S Ratio-15.7x
P/E RatioIs IOVA overvalued?
See Fair Value and valuation analysisEarnings & Revenue
| IOVA income statement (TTM) | |
|---|---|
| Revenue | US$324.97m |
| Cost of Revenue | US$167.68m |
| Gross Profit | US$157.29m |
| Other Expenses | US$446.80m |
| Earnings | -US$289.52m |
Last Reported Earnings
Jun 30, 2026
Next Earnings Date
n/a
| Earnings per share (EPS) | -0.64 |
| Gross Margin | 48.40% |
| Net Profit Margin | -89.09% |
| Debt/Equity Ratio | 0% |
How did IOVA perform over the long term?
See historical performance and comparisonCompany Analysis and Financial Data Status
| Data | Last Updated (UTC time) |
|---|---|
| Company Analysis | 2026/09/17 23:12 |
| End of Day Share Price | 2026/09/17 00:00 |
| Earnings | 2026/06/30 |
| Annual Earnings | 2025/12/31 |
Data Sources
The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.
| Package | Data | Timeframe | Example US Source * |
|---|---|---|---|
| Company Financials | 10 years |
| |
| Analyst Consensus Estimates | +3 years |
|
|
| Market Prices | 30 years |
| |
| Ownership | 10 years |
| |
| Management | 10 years |
| |
| Key Developments | 10 years |
|
* Example for US securities, for non-US equivalent regulatory forms and sources are used.
Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.
Analysis Model and Snowflake
Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.
Learn about the who designed and built the Simply Wall St analysis model.
Industry and Sector Metrics
Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.
Analyst Sources
Iovance Biotherapeutics, Inc. is covered by 21 analysts. 8 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.
| Analyst | Institution |
|---|---|
| Madhu Kumar | Baird |
| Colleen Kusy | Baird |
| null null | Baird |