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Maze Therapeutics, Inc.NasdaqGM:MAZE Stock Report

Market Cap US$1.4b
Share Price
US$25.75
US$62.55
58.8% undervalued intrinsic discount
1Y153.2%
7D-2.6%
1D
Portfolio Value
View

Maze Therapeutics, Inc.

NasdaqGM:MAZE Stock Report

Market Cap: US$1.4b

Maze Therapeutics (MAZE) Stock Overview

A clinical stage biopharmaceutical company, develops small molecule precision medicines for the treatment of kidney and metabolic diseases in the United States. More details

MAZE fundamental analysis
Snowflake Score
Valuation1/6
Future Growth2/6
Past Performance0/6
Financial Health5/6
Dividends0/6

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Maze Therapeutics, Inc. Competitors

Price History & Performance

Summary of share price highs, lows and changes for Maze Therapeutics
Historical stock prices
Current Share PriceUS$25.75
52 Week HighUS$53.65
52 Week LowUS$9.73
Beta0
1 Month Change0.23%
3 Month Change-41.77%
1 Year Change153.20%
3 Year Changen/a
5 Year Changen/a
Change since IPO61.44%

Recent News & Updates

Recent updates

Seeking Alpha Mar 27

Maze Therapeutics: MZE829 Presses Forward Despite Stock Price Drop

Summary I am initiating coverage on Maze Therapeutics (MAZE) with a "Buy" rating following positive phase 2 HORIZON data for MZE829 in APOL1-mediated kidney disease. MZE829 achieved a 35.6% mean reduction in proteinuria, exceeding the ≥30% uACR threshold required for clinical relevance and potential regulatory advancement. Despite a 37% stock drop post-data, I view the market reaction as overblown given the program’s success and planned pivotal trial initiation. The company maintains a strong cash position, funding operations into 2028, and has pipeline optionality with MZE782 targeting PKU and CKD in upcoming POC studies. Read the full article on Seeking Alpha
Analysis Article Dec 15

We're Not Worried About Maze Therapeutics' (NASDAQ:MAZE) Cash Burn

Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Seeking Alpha Mar 26

Maze Therapeutics: Interesting Science But IPO-Related And Other Risks Exist

Summary Maze Therapeutics, a kidney disease therapy developer, recently IPO-ed with a market cap of $487mn and significant early-stage investor backing. Lead asset MZE829 targets APOL1 Kidney Disease, showing promise in preclinical studies and currently in a phase 2 trial. Financials reveal a cash runway of 6.4 quarters from September, with significant R&D and G&A expenses, and a potential price drop post-lockup period. Due to the lack of proof of concept and potential pricing pressures, I recommend avoiding investment in Maze Therapeutics for now. Read the full article on Seeking Alpha

Shareholder Returns

MAZEUS PharmaceuticalsUS Market
7D-2.6%1.9%-0.8%
1Y153.2%41.8%27.1%

Return vs Industry: MAZE exceeded the US Pharmaceuticals industry which returned 38.7% over the past year.

Return vs Market: MAZE exceeded the US Market which returned 26.7% over the past year.

Price Volatility

Is MAZE's price volatile compared to industry and market?
MAZE volatility
MAZE Average Weekly Movement12.1%
Pharmaceuticals Industry Average Movement10.0%
Market Average Movement7.2%
10% most volatile stocks in US Market16.3%
10% least volatile stocks in US Market3.2%

Stable Share Price: MAZE's share price has been volatile over the past 3 months compared to the US market.

Volatility Over Time: MAZE's weekly volatility (12%) has been stable over the past year, but is still higher than 75% of US stocks.

About the Company

FoundedEmployeesCEOWebsite
2017141Jason Colomawww.mazetx.com

Maze Therapeutics, Inc., a clinical stage biopharmaceutical company, develops small molecule precision medicines for the treatment of kidney and metabolic diseases in the United States. Its lead programs include MZE829, an oral small molecule inhibitor of apolipoprotein L1, or APOL1, which is in phase II clinical trial for the treatment of patients with APOL1 kidney disease; and MZE782, an oral small molecule inhibitor that is in phase II ready clinical trial for the treatment of phenylketonuria and chronic kidney disease. The company also develops MZE001, an investigational oral small molecule inhibitor of muscle-specific glycogen synthase clinical program for the treatment of Pompe disease.

Maze Therapeutics, Inc. Fundamentals Summary

How do Maze Therapeutics's earnings and revenue compare to its market cap?
MAZE fundamental statistics
Market capUS$1.39b
Earnings (TTM)-US$122.54m
Revenue (TTM)US$20.00m
71.3x
P/S Ratio
-11.6x
P/E Ratio

Earnings & Revenue

Key profitability statistics from the latest earnings report (TTM)
MAZE income statement (TTM)
RevenueUS$20.00m
Cost of RevenueUS$0
Gross ProfitUS$20.00m
Other ExpensesUS$142.54m
Earnings-US$122.54m

Last Reported Earnings

Mar 31, 2026

Next Earnings Date

n/a

Earnings per share (EPS)-2.21
Gross Margin100.00%
Net Profit Margin-612.71%
Debt/Equity Ratio11.4%

How did MAZE perform over the long term?

See historical performance and comparison

Company Analysis and Financial Data Status

DataLast Updated (UTC time)
Company Analysis2026/05/21 08:56
End of Day Share Price 2026/05/21 00:00
Earnings2026/03/31
Annual Earnings2025/12/31

Data Sources

The data used in our company analysis is from S&P Global Market Intelligence LLC. The following data is used in our analysis model to generate this report. Data is normalised which can introduce a delay from the source being available.

PackageDataTimeframeExample US Source *
Company Financials10 years
  • Income statement
  • Cash flow statement
  • Balance sheet
Analyst Consensus Estimates+3 years
  • Forecast financials
  • Analyst price targets
Market Prices30 years
  • Stock prices
  • Dividends, Splits and Actions
Ownership10 years
  • Top shareholders
  • Insider trading
Management10 years
  • Leadership team
  • Board of directors
Key Developments10 years
  • Company announcements

* Example for US securities, for non-US equivalent regulatory forms and sources are used.

Unless specified all financial data is based on a yearly period but updated quarterly. This is known as Trailing Twelve Month (TTM) or Last Twelve Month (LTM) Data. Learn more.

Analysis Model and Snowflake

Details of the analysis model used to generate this report is available on our Github page, we also have guides on how to use our reports and tutorials on Youtube.

Learn about the world class team who designed and built the Simply Wall St analysis model.

Industry and Sector Metrics

Our industry and section metrics are calculated every 6 hours by Simply Wall St, details of our process are available on Github.

Analyst Sources

Maze Therapeutics, Inc. is covered by 12 analysts. 11 of those analysts submitted the estimates of revenue or earnings used as inputs to our report. Analysts submissions are updated throughout the day.

AnalystInstitution
Julian HarrisonBTIG
Debjit ChattopadhyayGuggenheim Securities, LLC
Ananda GhoshH.C. Wainwright & Co.